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In contrast to conventional paradigms, the emerging picture of the cell response to ionizing radiation speaks in favor of a complex response to a variety of radiation-induced signals with perturbations at the cellular and supracellular levels, where epigenetic changes have become increasingly recognized as important aspects besides the genetic ones (Figure 4)
Thats when the leptin circuit evolved

10.1038/nchembio.2238 76 KanaanM

A chronic, autoimmune condition, vitiligo is caused by a combination of factors, all of which inadvertently cause the destruction of the melanocytes, causing the development of white patches on the skin

doi: 10.1021/ac990998k

Niacinamide can improve overall skin health and resilience, which may help reduce pigmentation over time
