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Growth hormone activates a series of signaling pathways by binding to the growth hormone receptor (GHR) on the surface of target cells, thereby regulating various physiological processes such as growth, development, and metabolism in the body

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Access this article Similar content being viewed by others Abbreviations AGs: Argyrophilic grains ALS: Amyptrophic lateral sclerosis ALS/PDC: Guamanian ALSParkinsons disease complex AP: Astroglial plaque APP: Amyloid precursor protein AR-PD: Akinesia-and-rigidity type PD AS: -Synuclein AutD: Autosomal dominant AutR: Autosomal recessive Syn: -Synuclein BG: Basal ganglia BHC: Benign hereditary chorea BIBD: Basophilic inclusion body disease CAA: Cerebral amyloid angiopathy CAG: Polyglutamine CBD: Corticobasal degeneration CBGTC: Cortico-BG-thalamocortical CBS: Corticobasal syndrome ChAc: Chorea-acanthocytosis ChAT: Choline-acetyl transferase CI: Cognitive impairment CN: Caudate nucleus CNS: Central nervous system CSTD: Cortico-striataltemporal difference DA: Dopamine DLB: Dementia with Lewy bodies DLB-AD: Dementia with Lewy bodies and Alzheimers disease DRD: Dopa-responsive dystonia DRPLA: Dentatorubral-pallidoluysian atrophy DS: Dystonia syndrome ENK: Enkephalin ET: Essential tremor FTDP-17: Frontotemporal degeneration and parkinsonism linked to chromosome 17 FTLD: Frontotemporal lobar degeneration GABA: -Aminobutyric acid GBA: Glucocerebrosidase gene GCase: Glucocerebrosidase GCIs: Glial cytoplasmic inclusions GDNF: Glia-derived neurotrophic factor GNIs: Glial nuclear inclusions GPe: External segment of globus pallidus GPi: Internal segment of globus pallidus GTP: Guanosine triphosphate HD: Huntingtons disease HTT: Huntingtin iLBD: Incidental Lewy body disease IT: Intratelencephalic LB: Lewy body LC: Locus ceruleus LID: l-Dopa-induced dyskinesia LP: Lewy body pathology MCI: Mild cognitive impairment MD: Menkes disease MJD: Machado-Joseph disease MSA: Multiple system atrophy MSA-C: Multiple system atrophy with predominant cerebellar features MSA-P: Multiple system atrophy with predominant parkinsonism MSN: Medium spiny projection neuron NA: Neuroacanthocytosis NBIA: Neurodegeneration with brain iron accumulation NBM: Nucleus basalis of Meynert NCIs: Neuronal cytoplasmic inclusions NFTs: Neurofibrillary tangles NIID: Neuronal intranuclear inclusion disease NM: Neuromelanin NNIs: Neuronal nuclear inclusions NT: Neuropil threads OCD: Obsessive-compulsive disorder OPC: Olivopontocerebellar OPCA: Olivopontocerebellar atrophy OS: Oxidative stress pAS: Phosphorylated -synuclein PC: Purkinje cell PD: Parkinsons disease PDC: Parkinsons disease complex PDD: Parkinsons disease dementia PEP: Postencephalitic parkinsonism PGF: PSP with progressive gait freezing PHFs: Paired helical filaments PiD: Picks disease PKAN: Pantothenate-kinase associated neurodegeneration PPN: Pedunculopontine nucleus PPT: Pedunculo-pontine tegmental PSP: Progressive supranuclear palsy PSP-CBS: PSP presenting with corticobasal syndrom PSP-P: Progressive supranuclear palsy-parkinsonism PSP-RS: Richardsons syndrome Put: Putamen SCA3: Spinocerebellar ataxia type 3 SN: Substantia nigra SNc: Substantia nigra pars compacta SNr: Substantia nigra pars reticulata SP: Substance P STN: Subthalamic nucleus TA: Tufted astrocyte TDPD: Tremor-dominant type of PD TH: Tyrosine hydoxylase TS: Tourettes syndrome VaP: Vascular parkinsonism VM: Ventromedial VTA: Ventral tegmental area WD: Wilsons disease XDP: X-linked dystonia-parkinsonism References Aarsland D, Kurz MW (2010) The epidemiology of dementia associated with Parkinsons disease