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In mice lacking liver-specific IR, the nuclear active form of SREBP2 protein is drastically reduced in all feeding conditions, highlighting the dependency on insulin signaling for protein activation (221)

Third, the correlational design and limited sample size of our clinical study preclude definitive conclusions

180,181 The arginase isoenzymes arginase1 (ARG1) and arginase2 (ARG2) are abnormally upregulated in various cancers

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[DOI] [PubMed] [Google Scholar] 273.Stephens FB, Constantin-Teodosiu D, Laithwaite D, Simpson EJ, Greenhaff PL