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interference with the binding of IF-vitamin B12 complex to the cubilin receptors on the intestinal villi and enterocytes at the level of the ileum [14]

Curcumin, as a natural compound, has been shown to effectively inhibit signal transducer and activator of transcription 3 (STAT3) activity, thereby reversing its detrimental effects on the tumor microenvironment (Golmohammadi et al., 2024)

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Carmody M, Waszczak C, Idnheimo N, Saarinen T, Kangasjrvi J (2016) ROS signalling in a destabilised world: a molecular understanding of climate change

That was achieved by measuring brain oxidative stress biomarkers, brain-derived neurotrophic factor (BDNF), and HO-1 levels with an assessment of brain histopathology and determining the immunohistochemical caspase-3 as an apoptotic marker of brain tissue