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When Phase 1 activity exceeds Phase 2 capacity, reactive intermediate metabolites may accumulate faster than they can be neutralized
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However, despite the advantages of lipid-based nanodrug carriers, they still face challenges related to solubility, stability, and aggregation ( Polymer-based nanodrug carriers are another widely used carrier system, typically made from synthetic or natural polymer materials such as polylactic acid (PLA), polyethylene glycol (PEG), and poly (D,L-lactic-co-glycolic acid) (PLGA) (Shi et al., 2022)
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EAAT5 mediates glutamate release and light responses in depolarizing bipolar cells in the retina[207]
The GFP signal is visible exclusively in GFP ioGlutamatergic Neurons and absent in the wild-type control (lower panel)
