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This evidence leads us to hypothesize that, in the cortical motor areas of SMA mice, dysregulations in PV + IN GABA synthesis trigger a disruption of inhibitory neurotransmission in the late disease stage, which occurs simultaneously and in response to late-stage impairment of Gln neuron-astrocyte transport and/or metabolism
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Ringel AE, Drijvers JM, Baker GJ, Catozzi A, Garca-Caaveras JC, Gassaway BM, et al
