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doi: 10.1016/s0076-6879(99)01104-0

Liu J, Sukhova GK, Sun JS, Xu WH, Libby P, Shi GP

Rho0 cells are depleted of mitochondrial (mt) DNA, and thus exhibit functional impairments in Complexes I, III, IV, and V (protein subunits some of which are encoded by mtDNA), resulting in a loss of mitochondrial respiration 18

With regular use, skin looks firmer, smoother, and more elastic, with fewer fine lines and less crepey texture
