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Description
Since polyphenols can act as PAINS in biochemical assays (autofluorescence, redox cycling, aggregation, metal chelation), in-vitro hits without orthogonal validation were downgraded

Xiaolan Z, Jin Lin W, John L, Yanping S, Kwak KS, Qingsheng J, Robert R, Qing C, Thomas B

We sought to investigate this using young female and male APOE3 and APOE4 targeted replacement mice
doi:10.1016/j.smrv.2018.01.008

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Suggested Use: Take 1 tablet 1 to 2 times daily, preferably on an empty stomach
