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Recent findings reveal that various molecules and pathways, including nuclear receptor coactivator 4, astrocyte-derived lactate, low-density lipoprotein receptor-related protein 1, and cGAS signaling, can influence cerebral IRI progression through unique lactylation mechanisms or by directly regulating overall lactylation levels [113,114,115,116]

I., Romundstad P

One study of NAD 10mg/kg nasally administered to rats, two hours after ischemic brain injury, found significantly reduced ischemia-induced neurological deficits

Reckziegel, F

Yoshimoto et al., 2002)

Ferritin is the primary intracellular iron storage protein, composed of 24 light and heavy chain subunits forming a hollow spherical structure capable of binding up to 4,500 Fe + ions (41)