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The BCAA catabolic defect in these mice led to an impairment in cardiac contractility and greater susceptibility to heart failure

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First, we evaluated whether the downregulation of CPT1 using etomoxir affected mitochondrial dysfunction based on the normalized concentration of Cyt-c in the midbrain

Notably, the enantiomer D-carnitine may exert hepatotoxic effects ( Table 2 Human studies on L-carnitine supplementation in MASLD

Two studies observed no change (Fuller and Hoppel, 1988