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KJ Lenton, H Therriault, AM Cantin, T Fl p, H Payette, JR Wagner

Seminal carbohydrate in boar and stallion

Gallic acid improves cardiac dysfunction and fibrosis in pressure overload-induced heart failure

In conclusion, the study robustly demonstrated that FOXO4-DRI selectively eliminates senescent Leydig cells, reduces detrimental SASP factor secretion, improves the testicular microenvironment, and ultimately enhances sperm quality and spermatogenesis in aged mice, positioning it as a promising therapeutic candidate for age-related male infertility [2]

Reported tolerability in the available human observational work is high: no consistent pattern of adverse effects has been published, although the absence of placebo-controlled trials means subtle effects cannot be excluded

Two subsequent studies indicated that this sensitivity of microglia to ferroptosis may be regulated by the expression of intracellular NRF2 or iNOS (Qu et al., 2022)