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Arteriosclerosis thrombosis Vasc Biol (2003) 23(12):217884

In France, treatment involves the administration of 1,000 g (1 mg) of cyanocobalamin per day for 1 week, followed by 1,000 g (1 mg) per week for 1 month, followed by 1,000 g (1 mg) per month, again, normally for the remainder of the patients lifetime [10]

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Individuals who lack intrinsic factor (IF) are especially prone to pernicious anemia and neurological problems

The rationale for combining them is based on mechanistic complementarity (non-overlapping pathways), individual safety profiles, and clinical observations from practitioners administering the combination