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Of the six clinical trials included in the systematic review considered to have a low risk of selection bias due to adequate allocation concealment, only the RESTORE trial reported a notable benefit of treatment in preventing exacerbations [102]

Hydrogen sulfide SIBO is a newer category, typically associated with foul gas, sulfur odor, and a mix of symptoms

45 Glutathione Synthesis and Functions Glutathione (GSH) is a detoxifying agent in cells and one of the central mechanisms by which ROS are removed

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Physiological maintenance of SM requires injury or stretch stimulation, which prompts IGF-1 expression [35]

But concerns persist that ICS may reduce production of the steroid hormone cortisol in the body leading to adrenal suppression