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Nevertheless, cannabis is usually self-administered for its mood-altering properties, and has been described as an addictive, dependence-producing drug due to the production of euphoria, the presence of reversible psychological impairment, an abstinence syndrome, and tolerance

Biomolecules 5 (3), 21402159

Geun Lee, H

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This effect is mediated by 2 receptors and has been characterized most thoroughly on locus caeruleus neurons
doi: 10.1093/toxsci/61.2.218
