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E2 withdrawal suppresses sirtuin 1-mediated deacetylation of key metabolic enzymes, resulting in downregulation of IDH 3 (IDH3) and -KGDH, both rate-limiting enzymes in the TCA cycle (124,125)

It is well known that any delays in this debris clearance process significantly impairs the remyelination process 31

doi: 10.1038/s41598-019-41005-7 325 PalomaresL

MedDRAs hierarchical structure comprises five levels: System Organ Class (SOC), High-Level Group Term (HLGT), High-Level Term (HLT), Preferred Term (PT), and Lowest Level Term (LLT) 16

doi: 10.1016/j.envpol.2018.09.062 194 ConfalonieriMSaltonFFabianoF

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