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Endoplasmic reticulum stress and oxidative stress in cell fate decision and human disease

R.AlibolandiZ.SarkarP.GhazanfariM.Azami TamehA.et al (2021)

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Using the human ALS-linked superoxide dismutase 1 (SOD1 G93A ) mutant gene to replicate ALS in mice further highlighted the primary role of astrocyte: astrocyte-selective silencing of SOD1 alleviated ALS symptoms and increased life span 240,241 , whereas restricted expression of SOD1 in neurons did not cause pathology 242,243