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Historically the use of copper ionophores such as PBT2 have failed to produce efficacious results in clinical trials (Summers et al., 2022), but crucially they have been investigated without the addition of copper, probably due to the theory that it was primarily to disaggregate copper loaded plaques, in which case PBT2 would act as a chelator (Drew, 2017)

NF-B Inhibition & Tight Junction Restoration KPV enters cells and directly inhibits the NF-B transcription factor the master regulator of inflammatory gene expression

Choline is an important precursor to the neurotransmitter acetylcholine, which is involved in several important functions

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doi: 10.1038/nrrheum.2011.1 36 RadbruchAMuehlinghausGLugerEOInamineASmithKGCDrnerTet al

Glutathione acts to neutralize a toxic metabolic byproduct: Methylglyoxal Glutathione is involved in the protein disulfide bond rearrangement that is necessary for the synthesis of one third of the bodys proteins It protects the body from the oxidative damage caused by glutathione peroxidase by acting as a helper molecule for certain enzymes The liver uses Glutathione to help detoxify fats before the gallbladder emits bile, supporting healthy digestion Glutathione may also be crucial in the removal and detoxification of carcinogens, and according to recent studies17 alterations in this metabolic pathway, can influence cell survival profoundly