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By adding L-theanine to the drinking water of cirrhotic rats established by carbon tetrachloride, it was found that L-theanine inhibited the expression of NF-B, downregulated the pro-inflammatory cytokines (e.g., IL-1 and IL-6), and profibrotic mediators (e.g., transforming growth factor and connective tissue growth factor), and promoted the expression of anti-inflammatory cytokine IL-10 and fibrinolytic enzyme metalloproteinases-13 (85)

On the other hand, genome-wide association studies (GWAS) studies performed on ME/CFS patient samples from the U.K

Total Environ 2024, 946, 174300

Inhibition of the mitochondrial pyruvate carrier protects from excitotoxic neuronal death

A novel lysogenic adenovirus was engineered using the Tet-on system and delivered into human umbilical cord blood mesenchymal stem cells with IL-24 and endostatin genes to facilitate safe and effective glioma therapy through the modulation of viral replication [117]