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Experimental evidence has shown that statins, which inhibit 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase activity, can also increase the rate of ferroptosis by depleting cellular CoQ10 [61]

19), indicating potential toxicity beyond the 2.5 M dosage and poor target specificity

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Recent studies show that they exhibit anti-tumor activity by affecting multiple pathways including apoptosis, MAPK signaling, oxidative stress, and cell cycle progression

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