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Lysosomal Dysfunction in Down Syndrome Is APP-dependent and Mediated by APP-CTF (C99)

Contrary, NP4 showed a cytotoxic effect in the very low micromolar range (143B: IC 50 = 6.6 M, K7M2: IC 50 = 2.1 M) (drug-response curves: Fig

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When taken orally, penta deca peptide arginate contacts the stomach lining, small intestinal epithelium, and colonic tissue sequentially during transit

It is a structurally modified analogue with two deliberate pharmaceutical changes