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We have previously reported a maleimide group functionalized TPE (TPE-MI) for thiol sensing 26

Among the principal components, PC1 contributed the highest variance at 37.8% and 28.8%, PC2 contributed 20.91% and 14.12%, and PC3 contributed the lowest variance at only 8.9% and 7.77%, in the 3CQU-crocin and 3CQU-troriluzole complexes, respectively

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These challenges span mechanistic understanding, therapeutic design, and clinical validation

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