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This study aimed to identify potential activators of GPx4, an essential inhibitor to ferroptosis, as a novel neuroprotective strategy in MS treatment

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It is also a highly effective antioxidant that can protect the body's cells and molecules from damage by free radical and reactive oxygen molecules generated during normal metabolism and exposure to environmental stressors

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Methods We developed a novel approach to identify anticipated events for a hypothetical randomized, double-blind, controlled trial in subjects with bipolar disorder using the adverse events reported in the placebo arm of trials from the ClinicalTrials.gov database