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Mechanistically, DNA damage, A toxicity, cholesterol dysregulation, iron/copper dysregulation, inflammation, and oxidative stress may be implicated in myelin pathology in AD

10.1016/j.cmet.2016.08.021 Cell Metab

Early concerns about stem cells potentially becoming cancerous have not been borne out in clinical practice, though long-term data collection continues

Oxidative stress injury in doxorubicin-induced cardiotoxicity

PCOS model was established by orally administering letrozole to rats, which confirmed that Shaoyao-Gancao Decoction significantly reduced the ratio of Firmicutes to Bacteroidetes, decreased the LPS-producing pathogen Proteobacteria, increased the abundance of Butyricicoccus, Coprococcus, Akkermansia, Blautia and Bacteroides, and improved the polycystic symptoms in PCOS rats (49)

doi: 10.1056/NEJMoa1708423
