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The fully conserved KTxxxW domain is an intracellular domain at the C-terminal side of FZD proteins and interacts with the protein-95/discs-large/zona occludens-1 (PDZ) domains of DvL proteins

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It can also help protect against atherosclerosis 31 , or hardening of the arteries, a major cause of heart disease

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Secondly, it indirectly fosters GSH synthesis to lymphocytes and thereby regulates their proliferation and activation ( Figure 1 )