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Upon stimulation by MCP-1 and TNF-, monocytes differentiate into macrophages
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Detailed evidence is provided by the study of Zhu, that when neurexin-1 is transcriptionally repressed and activated in neurons in vitro, it is enriched around its promoter by synthesizing zinc-finger protein (ZFP) to histone methyltransferase (Ash1L) and histone marker H3K36me2, respectively, and that the transcriptional repression of neurexin-1 disappears when Ash1L is turned off [85]
