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[DOI] [PMC free article] [PubMed] [Google Scholar] 214

Nutritional Supplements Targeted supplements can support brain function, reduce inflammation, and enhance recovery

Hyperpigmentation, specifically involving the knuckles has been described in vitamin B12 deficiency, but usually,these patients are symptomatic with systemic manifestations like megaloblastic anemia, pancytopenia, or neurological deficits
10.1523/JNEUROSCI.0979-11.2011 133.Feusner J , Ritchie T , Lawford B , Young RM , Kann B , Noble EP

Restoring adequate intake through vitamin C-rich foods can support tissue regeneration and improve microvascular integrity [73,128]
Bile acid synthesis in humans: regulation of hepatic microsomal cholesterol 7-hydroxylase activity
