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Effect of circulating IGF-1 on the retina IGF-1R is activated by the ligand IGF-1, and the liver is the major site of IGF-1 production [29]

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Spirulina is not a good source of B12 and only contains B12 analogues Because vitamin B12 is water-soluble it's extremely hard to overdose, and because the body is quite inefficient at absorbing B12, supplements often contain 10,000% RDA, sometimes even 100,000% RDA, to try and ensure the body actually absorbs some of it

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[DOI] [PubMed] [Google Scholar] 309.Youle RJ, Karbowski M