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Previous studies in rodents have shown that colistin-induced apoptosis involves both the mitochondrial (e.g., downregulation of Bcl-2 and upregulation of cytochrome C and Bax) and the ER pathways (upregulation of Grp78) 20,21

It modulates metabolic pathways, including pyruvate dehydrogenase activity, proteolysis, and protein synthesis, while also having anti-inflammatory and antioxidant characteristics

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Lai YH, Lee MC, Ho GJ et al (2019) Association of low serum L-carnitine levels with peripheral arterial stiffness in patients who undergo kidney transplantation

Enzymatic assays revealed the plasma and hepatic TC and TG levels