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However, biological barriers such as efflux transporters may limit the absorption of orally administered drugs including peptides

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To test this hypothesis, we used several ovarian cancer cell lines, including serous carcinoma (OSC - OVCAR3 and OVCAR8), sensitive and resistant to Cisplatin A2780 (A2780 parental and A2780 cisR) unspecified histotype ovarian carcinoma cells and clear cell carcinoma (OCCC-ES2) cells

Evidence Considering a high K m value for L-arginine as substrate for arginase (13 mM), it has been reasoned that the main function of arginase is to limit the intracellular accumulation of L-arginine