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Epithalon (also spelled Epitalon or Epithalone) is a synthetic tetrapeptide a chain of four amino acids with the sequence Ala-Glu-Asp-Gly

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The peptide upregulates MMP-2 expression in dermal fibroblasts by 85%, facilitating breakdown of damaged collagen and enabling cellular migration through dense matrix environments, while simultaneously enhancing production of tissue inhibitors of metalloproteinases (TIMPs) to prevent excessive degradation