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The gut microbiota depends on the mucus layer which serves as an energy source for bacteria

Mechanistic studies in animal models suggest that mucosal targeting is likely to offer better protection against respiratory infections [43], but methods for inducing mucosal immunity are in the earliest stages of testing

Studies even suggest that choline supplementation may stave off fatigue in athletes ( 7 )

Let's work backward

Because the decline in prescribing primarily involved adults who reported moderate or more severe pain, these trends raise questions about whether efforts to decrease opioid prescribing have successfully focused on adults who report less severe pain." Mark Olfson, Shuai Wang, Melanie M