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RN-1, a potent and selective lysine-specific demethylase 1 inhibitor, increases -globin expression, F reticulocytes, and F cells in a sickle cell disease mouse model

miR-125a-5p and specific protein 1 (SP1) expression, inflammation-related factors IL-6 and IL-10, and apoptosis were detected in mice

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These effects were further reconfirmed by the electron microscopic study of brain which showed discontinuous myelin sheath around the axon including swollen mitochondria, blebbed nucleus as well as nuclear membrane changes with the treatment of mercuric chlo- ride

In addition, gut can be influenced by brain injury through neuroregulation