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However, in addition to their ability to directly interact with biological molecules (lipids, proteins or nucleic acids), ROS damage also involves the alteration of signaling pathways, such as activation of the NF- pathway, which in turn activates the gene expression of several pro-inflammatory cytokines [16,19,26]

Gadd45a suppresses tumor angiogenesis via inhibition of the mTOR/STAT3 protein pathway

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In the comparison of the young WT and Mda5 -/- HSCs, we found 1.723 regions that were mostly accessible in WT (reduced peaks), and 10.694 mostly accessible in Mda5 -/- HSCs (induced peaks) (Fig

Over the years, many such novel metabolites were uncovered, referred to as GSH S-conjugates or GSH adducts, which were assigned their name by the chemical entity adducted

Blocking glutathione regeneration: Inorganic NADPH oxidase nanozyme catalyst potentiates tumoral ferroptosis