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10.1038/nm.2819 Nat

It reduces the appearance of wrinkles by suppressing excessive fibroblast contraction and stimulates collagen production

However, to date, oligonucleotide therapeutics are still facing some technological obstacles, such as how to achieve efficient oligonucleotide delivery to target organs or tissues, how to overcome off-target interactions [4952], and how to address the sequence- and chemistry-dependent toxicity and saturation of endogenous RNA processing pathways [53, 54]

Methylation of the BSH cysteinyl amine presumably stabilizes the thiolate anion which may further lower the thiol p K a [54]

Importantly, pharmacological modulation of NRF2 has emerged as a promising therapeutic strategy