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References Alikhani N, Ankarcrona M, Glaser E (2009) Mitochondria and Alzheimers disease: amyloid-beta peptide uptake and degradation by the presequence protease, hPreP

Int J Pediatr Otorhinolaryngol 100:247253 Koch M, Schnitzler HU (1997) The acoustic startle response in rats--circuits mediating evocation, inhibition and potentiation

Michael Gnzle, University of Alberta, Canada

Multimodal imaging combining PET and MRS in CHR-P individuals found a negative correlation between hippocampal glutamate levels and striatal dopamine synthesis capacity, this was particularly marked in the CHR-P individuals who later transitioned to psychosis [64]

In mice, AKR1B1 inhibition reduced airway inflammation, hyperresponsiveness and IgE and Th2-cytokine levels in ovalbumin and ragweed pollen extract-induced asthma (Yadav et al., 2009, 2011a)

The GLP-1 and GIP arms slow gastric emptying and blunt appetite (that is where nausea comes from), while the glucagon arm nudges energy expenditure and hepatic fat handling