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Treatment with GSTO1-specific siRNA significantly decreased the viability of HCT116 cancer cells (Fig

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10.14336/AD.2019.0508 [DOI] [PMC free article] [PubMed] [Google Scholar] 292.Draganidis D, Karagounis LG, Athanailidis I, Chatzinikolaou A, Jamurtas AZ, Fatouros IG

Our study demonstrates that supplementing with -ketoglutarate, the -keto acid of glutamine, can serve as an alternative metabolite to mitigate systemic glutamine dependence, glucose intolerance and simultaneously address concerns related to ammonia neurotoxicity

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GA decreases the activity of catalase (CAT), ascorbate peroxidase (APX), and superoxide dismutase (SOD), leading to reduced scavenging ability for ROS, consequently resulting in peroxidative damage of membranes followed by release of hydrolytic enzymes (Jones and Smirnoff, 2005