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Cisplatin induces BDNF downregulation in middle-aged female rat model while BDNF enhancement attenuates cisplatin neurotoxicity

Gastrointestinal symptoms (more common with oral preparations): Mild nausea or upset stomach Diarrhoea (typically with very high doses) Other effects: Headache, particularly when treatment is first initiated Dizziness or light-headedness Skin reactions such as mild rash or itching Temporary reddish discolouration of urine (chromaturia) after hydroxocobalamin injections, which is harmless It is important to note that many symptoms attributed to B12 supplementation may actually represent the body's response to correcting a deficiency

Important genes in the pathogenesis of endometriosis may not be adequately covered to fully investigate the epigenetic roots of endometriosis

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Colon length, a macroscopic indicator of intestinal inflammation, was markedly reduced in ABX/LPS-challenged mice, reflecting severe colitis

Since the number of dropouts was expected to be small because of the short, 3-month study period, we performed an intermediate analysis to test for significant differences