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Firstly, the main strength is the long study follow-up (15 months), which allows for gathering information about potential changes in patients QoL in response to long-term ALC treatment, usually not be easily detectable in studies with shorter observation periods

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The gut microbiota mediates the anti-seizure effects of the ketogenic diet

More research in this area is warranted to strengthen the prognostic usefulness of long-chain ACs and to further elucidate the perturbed mitochondrial pathways as potential therapeutic targets

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