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Ethics declarations Competing interests KGW and VJNB are co-founders and shareholders of Aprea Therapeutics AB, a company that develops novel p53-based cancer therapy

Additionally, the controllable and tunable fluorescence properties of CDs, which can be modulated by preparation methods and precursor materials, make them highly promising for drug analysis, as changes in their fluorescence intensity or state can be induced by external stimuli 19,28,29,30,31

Physical activity and exercise improve the body's antioxidant system, which aids in the management of OS by scavenging harmful free radicals, and alters cell-signaling pathways, which activate detoxification enzymes, reduce inflammation, promote normal cell cycle, inhibit proliferation, induce apoptosis, and prevent tumor invasion and angiogenesis (101)

RRBS, reduced representation bisulfite sequencing

doi: 10.1371/journal.pmed.0040158