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These therapies utilize agents that are not microbicides per se, but rather their action is directed by modulating host cell immunity ( Leishmania to endogenous microbicidal mechanisms of macrophages, various agents have been used to unlock the microbicidal functions that the parasite is able to encrypt, including toll-like receptors (TLR) agonist like Imiquimod and CpGs oligonucleotides ( One of the most intriguing battles between Leishmania and the macrophage is the competition for iron, an essential element for the survival and functions of both

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