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10.3174/ajnr.A1820 314 YoonJ

Immunocal Protects HT22 Mouse Hippocampal Cells from Toxicity Induced by Overexpression of Amyloid-Beta Peptide (A 1-42 ) A 1-42 is the major constituent of senile plaques, which form in the brains of Alzheimer's patients, leading to the hypothesis that increased production of this protein from aberrant processing of amyloid precursor protein is a major contributor to neuronal death and disease pathogenesis [48]

This is the dose studied in every FDA registration trial and the dose carried forward in long term extension work

[DOI] [PubMed] [Google Scholar] 34.Zhang D, Jia H, Wang Y, Li WM, Hou YC, Yin SW, Wang TD, He SX, Lu SY

Currently, antibodies like aducanumab ( 1 ), lecanemab ( 2 ), and donanemab ( 10 ) show their promise in proving A as a significant factor in AD development

Rats were housed in an SPF-grade environment with controlled temperature and humidity and were free of specific pathogens