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proposed a novel pathway for renal anemia based on an in vitro test evaluating the cytotoxic effect of uremic plasma on healthy RBCs and CD14 ++ /CD16 + monocytes

it is a water soluble vitamin and also called cobalamin

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ROS dysregulation in digestive diseases The perturbation in ROS equilibrium has been implicated as a key driver of disease pathogenesis and progression in various digestive disorders [360]

In mammalian tissues, they also serve as scavengers of oxygen free radicals, effectively preventing oxidative stress-induced mitochondrial damage and mitochondria-dependent apoptosis in a variety of cell types 32,33,34

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