nrf2 glutathione peroxidase schizophrenia Molecular Medicine Reports Recent Advances in Understanding Nrf2

19 Clinical uses Alzheimers disease/cognitive function Oxidative stress has been implicated in neurodegenerative conditions and impaired cognitive function and, in animal models, NAC has been shown to have a beneficial effect on cognitive function

While antibody brain shuttles are mostly restricted to TfR1, peptide sequences for brain delivery have been directed against a wide variety of receptors, ranging from TfR1 to LRP1, LRP2, LDLRs, integrin receptors, nAchR, or a glutathione transporter

M.ParkS.JungE.KoD.ParkM.et al (2023)

These defects manifest in various organs with diverse symptoms

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doi: 10.1523/JNEUROSCI.4182-09.2010 39 ChewEYClemonsTEJaffeGJJohnsonCAFarsiuSLadEMet al