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doi: 10.1038/nm.2679 32 McClainJGrubiiVFriedDGomez-SuarezRALeinningerGMSvignyJet al

Over 96 weeks, 178 (44%) of 402 patients in the cladribine 3.5 mg/kg group and 189 (46%) of 411 patients in the cladribine 5.25 mg/kg group were free from disease activity versus 60 (16%) of 379 patients in the placebo group

In inflammatory contexts, NF-kB suppression is particularly relevant because chronic NF-kB activation drives the disruption of tight junction proteins (claudin, occludin) that characterizes increased intestinal permeability in colitis models

This action promotes connective tissue integrity during the physical changes that accompany significant fat loss

10.1186/s40425-019-0520-5 240

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