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Pharmacodynamics: The observed pharmacodynamic effects in animal models often outlast measurable systemic exposure, suggesting mechanisms that include local tissue modulation, induction of growthfactor expression, and initiation of reparative cascades rather than sustained receptor occupancy requiring prolonged systemic presence

COL5A1 signal peptide mutations interfere with protein secretion and cause classic EhlersDanlos syndrome

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[DOI] [PubMed] [Google Scholar] 17.Juan, C

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