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[19] [20] XPCS and TTD fibroblasts from ERCC2 (XPD) mutant human and mouse show evidence of defective repair of oxidative DNA damages that may underlie the segmental progeroid (premature aging) symptoms [21] (see DNA damage theory of aging)

Hidalgo, H

Measuring 3-hydroxyisovaleric acid has been shown to be the most sensitive marker of biotin deficiency [8]

Nature 604 , 349353 (2022)

10.1111/j.1473-2165.2007.00288.x 65 FiscusV.HankinsonA.AlweisR

Studies have shown that dyspnea in asthma patients can trigger abnormal activity in brain regions involved in emotional regulation (e.g., the insula), leading to a reduced emotional control capacity and a predisposition to anxiety and depression [71, 459]
