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Koutakis P, Ismaeel A, Farmer P, Purcell S, Smith RS, Eidson JL, Bohannon WT

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We hypothesize that irisin reduces lactate synthesis by inhibiting the HIF-1/LDHA pathway via SIRT1-mediated deacetylation and repairs mitochondrial function through the PGC-1/UCP2 pathway, ultimately improving neuronal damage

The reduced expression of SOD-B leads to rapid accumulation of superoxide anion within the trypanosome responsible for detoxifying highly toxic radical in the parasite [74]

In contrast, the activation of nuclear receptor kappa B (NR-B) promotes processes that support survival and the maintenance of an optimal number of neuronal cells

By assigning metabolites to the signals shown in the loading plot (Figs 4B and S5B) and quantifying the variation observed for each metabolite among the different classes, we found that overall, vB12 treatment induced significant metabolic changes in Tbx1 +/ mice only (Figs 4A, S5A, and S6, Table S1, Group 3)