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The remainder can be transported to the liver via the portal vein circulation, and in there it would be oxidized into TMAO by the host liver flavin monooxygenases (FMO1 and FMO3) (Lang et al., 1998

Moreover, allelic and tissue-specific differences in the regulation of PGC-1 have been observed between brown adipocytes in white fat and classical interscapular brown fat, implying distinct regulatory mechanisms that determine the thermogenic capacity of these depots [87]

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