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It is noteworthy that clinical studies have revealed an upregulation in the expression of STAT3 within the intestinal mucosa of individuals suffering from IBD (Li et al., 2010)

Identification of 4,6-dioxoheptanoic acid (succinylacetone), 3,5-dioxooctanedioic acid (succinylacetoacetate) and 4-oxo-6-hydroxyheptanoic acid in the urine from patients with hereditary tyrosinemia

However, these observations are apparently specific to transformed cells as a recent report showed that in PHH and in the non-transformed cell line HepaRG, ribavirin does not induce but rather represses and resets the expression of ISGs by chromatin remodeling (177)

Transl Neurodegener 6:8 Safar MM, Abdelkader NF, Ramadan E, Kortam MA, Mohamed AF (2021) Novel mechanistic insights towards the repositioning of alogliptin in Parkinsons disease

Moreover, the authors suggested that the presence of AHK-Cu may have reduced the number of apoptotic dermal papilla cells

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