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Anatomically, the nasal cavity can be divided into the vestibule, respiratory region, olfactory region, and nasal-associated lymphoid tissue (NALT) located mainly in the nasopharynx (Fig

Among CD4 + T cell populations, T H 1 and T H 17 cells are particularly implicated in MS pathogenesis and exhibit elevated expression of their signature cytokines, IFN- and IL-17A, respectively ( FIGURE 2 As the disease progresses, diffuse infiltration of inflammatory T cell occurs, accompanied by the release of pro-inflammatory cytokines such as TNF-, IL-1 and IL-6

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Additionally, preliminary findings showed that when P